Securing communication and collaboration applications tailored for the cloud, such as Microsoft Exchange Online, OneDrive, SharePoint Online, and Teams, is crucial in the contemporary digital landscape. Although Microsoft’s inherent security measures offer a fundamental level of protection, it falls short in addressing the full spectrum of cyber threats. A comprehensive solution designed to enhance security for Microsoft Office 365 goes beyond conventional measures, safeguarding against both known and unknown threats. Leveraging advanced heuristics, machine learning, and other cutting-edge technologies, this solution shields cloud-centric enterprises from diverse risks, including ransomware, malicious attachments, spam, phishing, Business Email Compromise (BEC), and emerging threats.